Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve
Identifieur interne : 001366 ( Main/Exploration ); précédent : 001365; suivant : 001367Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve
Auteurs : Huw G. Jenkins [Royaume-Uni] ; Hisako Ikeda [Royaume-Uni]Source :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1992.
English descriptors
- Teeft :
- Axonal, Axonal transport, Blood vessel, Colliculi, Colliculus, Demyelination, Electron micrograph, Ikeda, Intraocular injection, Intravitreal, Intravitreal injection, Intravitreal injections, Liquid scintillation, Mouse, Mouse vitreous, Multiple sclerosis, Myelin, Myelin destruction, Myelinated axons, Nude mice, Optic, Optic nerve, Optic nerve demyelination, Optic nerve fibres, Optic nerve section, Optic nerve sections, Optic nerves, Retina, Rtnf, Rtnf injection, Sclerosis, Semliki, Semliki forest virus, Semliki forest virus infection, Superior colliculi, Superior colliculus, Tansey, Units rtnf.
Abstract
Abstract: An increase in fast axonal transport of protein by the optic nerve was found in mice following a single combined injection of human recombinant tumour necrosis factor alpha (rTNF) and [3H]proline into the vitreous chamber. Demyelination was observed in optic nerve fibres arising from the eyes of mice which received a single rTNF injection. No such changes were detected when heat-inactivated rTNF was injected with the label. The effects of intravitreal injection of rTNF on the pathophysiology of mouse optic nerve resembled those found in mice infected with Semliki Forest virus (SFV), an animal model of multiple sclerosis. We suggest that TNF could mediate at lease some of the pathophysiological changes found in SFV-infected mice and may provide a clue concerning the disease mechanism in multiple sclerosis.
Url:
DOI: 10.1016/0022-510X(92)90194-P
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000270
- to stream Istex, to step Curation: 000250
- to stream Istex, to step Checkpoint: 000529
- to stream Main, to step Merge: 001384
- to stream Main, to step Curation: 001366
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve</title><author><name sortKey="Jenkins, Huw G" sort="Jenkins, Huw G" uniqKey="Jenkins H" first="Huw G." last="Jenkins">Huw G. Jenkins</name></author><author><name sortKey="Ikeda, Hisako" sort="Ikeda, Hisako" uniqKey="Ikeda H" first="Hisako" last="Ikeda">Hisako Ikeda</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1E460BBF817D9AE0F731B027925B861DB71C1248</idno><date when="1992" year="1992">1992</date><idno type="doi">10.1016/0022-510X(92)90194-P</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-PRPBKB5W-M/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000270</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000270</idno><idno type="wicri:Area/Istex/Curation">000250</idno><idno type="wicri:Area/Istex/Checkpoint">000529</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000529</idno><idno type="wicri:doubleKey">0022-510X:1992:Jenkins H:tumour:necrosis:factor</idno><idno type="wicri:Area/Main/Merge">001384</idno><idno type="wicri:Area/Main/Curation">001366</idno><idno type="wicri:Area/Main/Exploration">001366</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve</title><author><name sortKey="Jenkins, Huw G" sort="Jenkins, Huw G" uniqKey="Jenkins H" first="Huw G." last="Jenkins">Huw G. Jenkins</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Vision Research Unit of Sherrington School (UMDS), The Rayne Institute, St. Thomas' Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ikeda, Hisako" sort="Ikeda, Hisako" uniqKey="Ikeda H" first="Hisako" last="Ikeda">Hisako Ikeda</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Vision Research Unit of Sherrington School (UMDS), The Rayne Institute, St. Thomas' Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="ISSN">0022-510X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">108</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="99">99</biblScope><biblScope unit="page" to="104">104</biblScope></imprint><idno type="ISSN">0022-510X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Axonal</term><term>Axonal transport</term><term>Blood vessel</term><term>Colliculi</term><term>Colliculus</term><term>Demyelination</term><term>Electron micrograph</term><term>Ikeda</term><term>Intraocular injection</term><term>Intravitreal</term><term>Intravitreal injection</term><term>Intravitreal injections</term><term>Liquid scintillation</term><term>Mouse</term><term>Mouse vitreous</term><term>Multiple sclerosis</term><term>Myelin</term><term>Myelin destruction</term><term>Myelinated axons</term><term>Nude mice</term><term>Optic</term><term>Optic nerve</term><term>Optic nerve demyelination</term><term>Optic nerve fibres</term><term>Optic nerve section</term><term>Optic nerve sections</term><term>Optic nerves</term><term>Retina</term><term>Rtnf</term><term>Rtnf injection</term><term>Sclerosis</term><term>Semliki</term><term>Semliki forest virus</term><term>Semliki forest virus infection</term><term>Superior colliculi</term><term>Superior colliculus</term><term>Tansey</term><term>Units rtnf</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: An increase in fast axonal transport of protein by the optic nerve was found in mice following a single combined injection of human recombinant tumour necrosis factor alpha (rTNF) and [3H]proline into the vitreous chamber. Demyelination was observed in optic nerve fibres arising from the eyes of mice which received a single rTNF injection. No such changes were detected when heat-inactivated rTNF was injected with the label. The effects of intravitreal injection of rTNF on the pathophysiology of mouse optic nerve resembled those found in mice infected with Semliki Forest virus (SFV), an animal model of multiple sclerosis. We suggest that TNF could mediate at lease some of the pathophysiological changes found in SFV-infected mice and may provide a clue concerning the disease mechanism in multiple sclerosis.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Jenkins, Huw G" sort="Jenkins, Huw G" uniqKey="Jenkins H" first="Huw G." last="Jenkins">Huw G. Jenkins</name></region><name sortKey="Ikeda, Hisako" sort="Ikeda, Hisako" uniqKey="Ikeda H" first="Hisako" last="Ikeda">Hisako Ikeda</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001366 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001366 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:1E460BBF817D9AE0F731B027925B861DB71C1248
|texte= Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve
}}
| This area was generated with Dilib version V0.6.33. |  |